Key result
Strontium replaces calcium to fully activate myofibrillar ATPase in frog skeletal muscle despite lower affinity.
Population
Frog skeletal muscle
Comparison
Replacement of calcium by strontium vs Calcium
Design
Preclinical
Authors
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No clinical implications; leaves open strontium substitution for calcium in mammalian excitation-contraction coupling.
Strontium can substitute for calcium in several aspects of excitation-contraction coupling in frog skeletal muscle, albeit generally with lower efficacy or affinity.
Edwards et al. (1966) studied this question. Strontium vs. Calcium was evaluated on Excitation-contraction coupling and myofibrillar ATPase activation. In frog skeletal muscle, strontium can replace calcium in potassium contractures and fully activate myofibrillar ATPase, though with less affinity and effectiveness than calcium.
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