Key result
Substitution of calcium with strontium increased contraction duration and time-to-peak tension in rat heart ventricles across all age groups, while contractile force increased only in neonates.
Population
Isolated ventricular muscle from postnatally developing rat hearts (neonates to adult rats)
Comparison
Substitution of calcium by an equimolar… vs Calcium-Tyrode solution
Design
Preclinical
Authors
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Cautions against extrapolating rat strontium data to human neonates; leaves open mechanistic role of T-system maturation in postnatal calcium efficiency.
The study demonstrates that qualitative changes in the contractile properties of developing rat hearts during the 3rd postnatal week are likely due to more efficient utilization of intracellular calcium stores linked to T system development.
Matti Vornanen (1985) studied Postnatally developing rat heart ventricles. Strontium substitution for calcium vs. Calcium (Ca-Tyrode) was evaluated on Isometric contractions (duration, time-to-peak tension, contractile force). Substitution of calcium with strontium increased contraction duration and time-to-peak tension in rat heart ventricles across all age groups, while contractile force increased only in neonates.
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