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During postnatal development in rats, the increase in heart rate and shortening of contraction duration correlate with a shift toward intracellular calcium utilization, and the presence of a negative force-frequency staircase across developmental stages indicates it is driven by sarcoplasmic reticulum calcium regulation mechanisms rather than just the quantitative contribution of the sarcoplasmic reticulum. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 1, 1992Acta Physiologica Scandinavica

Force‐frequency relationship, contraction duration and recirculating fraction of calcium in postnatally developing rat heart ventricles: correlation with heart rate

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MVMatti VornanenUniversity of Eastern Finland

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Implication

Rat developmental HR-contraction patterns warrant no clinical extrapolation; leaves open human force-frequency maturation mechanisms.

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Matti Vornanen (1992) studied this question.

synapsesocial.com/papers/6a1ebc8f6b4935698da443a7 https://doi.org/10.1111/j.1748-1716.1992.tb09371.x

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Force‐frequency relationship, contraction duration and recirculating fraction of calcium in postnatally developing rat heart ventricles: correlation with heart rate

Discussion

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Implication

Key Points

Cite This Study

Force‐frequency relationship, contraction duration and recirculating fraction of calcium in postnatally developing rat heart ventricles: correlation with heart rate

Discussion

Member takes

Implication

Key Points

Cite This Study

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