Key result
Supra-physiological pacing rates up to 30 Hz in isolated rat myocardium produced mechanically stable steady-state contractions with declining amplitude and increased diastolic force.
Why the study?
Does supra-physiological stimulation frequency alter amplitude and kinetics of contraction in multicellular trabeculae isolated from rat hearts?
Population
Multicellular trabeculae isolated from rat hearts
Comparison
Supra-physiological stimulation frequency vs Normal in vivo rat heart range (e.g., 1 Hz)
Design
Preclinical
Authors
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Findings in rat trabeculae should not yet alter clinical VF management; leaves open translation to human myocardial mechanics.
Does supra-physiological stimulation frequency alter amplitude and kinetics of contraction in multicellular trabeculae isolated from rat hearts?
Isolated rat myocardium maintains mechanically stable steady-state contractions at supra-physiological pacing rates, though with declining amplitude and increased diastolic force, providing insight into myocardial mechanics during ventricular fibrillation.
Slabaugh et al. (2012) studied this question. Supra-physiological stimulation frequency vs. Normal in vivo heart rates was evaluated on Amplitude and kinetics of contraction and occurrence of mechanical alternans. Supra-physiological pacing rates up to 30 Hz in isolated rat myocardium produced mechanically stable steady-state contractions with declining amplitude and increased diastolic force.
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