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September 1, 1990Circulation ResearchOpen Access

Developmental changes in cardiac myocyte calcium regulation.

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Population

Isolated ventricular myocytes from neonatal and adult New Zealand White rabbits

Comparison

Extracellular Ca2+ reduction and ryanodine… vs Comparison between neonatal and adult myocytes

Design

Preclinical

Authors

TCThomas K. ChinWFWilliam F. FriedmanTKThomas S. Klitzner

Discussion

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Overview

This preclinical study demonstrates that neonatal cardiac myocytes rely more on transsarcolemmal calcium influx for contraction, whereas adult myocytes depend more on intracellular calcium release.

Structured PICO

P
Population
Isolated ventricular myocytes from neonatal (aged 1-7 days) and adult (aged 8-10 weeks) New Zealand White rabbits
I
Intervention
Extracellular Ca2+ reduction (1mM to micromolar levels) and ryanodine perfusion (1 or 10 microM)
C
Comparator
Comparison between neonatal and adult myocytes
O
Outcome
Myocardial contraction amplitude and recoverysurrogate

This preclinical study demonstrates that neonatal cardiac myocytes rely more on transsarcolemmal calcium influx for contraction, whereas adult myocytes depend more on intracellular calcium release.

Cite This Study

Chin et al. (1990) studied this question.

synapsesocial.com/papers/6a7dfd45f980e836411884c0https://doi.org/10.1161/01.res.67.3.574
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Developmental changes in myocardial mechanical function and subcellular organelles1984 · 131 citations
  2. 2Differentiation of sarcoplasmic reticulum during cardiac myogenesis1987 · 65 citations
  3. 3Changes in the calcium current of rat heart ventricular myocytes during development.1988 · 174 citations
  4. 4Developmental changes in cardiac sarcoplasmic reticulum in sheep.1986 · 138 citations
  5. 5Cumulative depletions of extracellular calcium in rabbit ventricular muscle monitored with calcium-selective microelectrodes.1986 · 38 citations