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April 1, 1984AJP Heart and Circulatory Physiology

Developmental changes in myocardial mechanical function and subcellular organelles

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Population

Isolated, arterially perfused hearts of fetus, newborn, and adult rabbits

Comparison

Various extracellular calcium concentrations vs Comparison across developmental stages

Design

Preclinical

Authors

TNToshio NakanishiJJJay M. Jarmakani

Discussion

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Overview

Developmental increases in myocardial contractility are driven by changes in intracellular calcium handling, myofibrillar content, and ATPase activity.

Key Points

  • This research aims to explore how the mechanical function of the heart and subcellular organelle activities change during development.
  • Isolated, arterially perfused hearts from fetus (28 days gestation), newborn (3-5 days old), and adult rabbits were examined.
  • Mechanical function was evaluated at varying calcium concentrations ([Ca2+]0).
  • Myofibrillar content and ATPase activity were compared across developmental stages.
  • Maximal force of contraction was significantly lower in fetus (7.5 mM [Ca2+]0) compared to newborn (30 mM [Ca2+]0) and adult (15 mM [Ca2+]0).
  • Both myofibrillar content in the fetus and ATPase activity in the fetus and newborn were significantly less than in adults at pCa 4 and 5.
  • Sarcoplasmic reticulum Ca2+ uptake increased with age, while mitochondrial Ca2+ uptake was higher in newborns than in fetuses and adults at physiological pCa levels.

Structured PICO

P
Population
Isolated, arterially perfused hearts of fetus (28th day of gestation), newborn (3-5 day old), and adult rabbits
I
Intervention
Various extracellular calcium concentrations ([Ca2+]0)
C
Comparator
Comparison across developmental stages (fetus vs. newborn vs. adult)
O
Outcome
Myocardial mechanical function (maximal force of contraction) and function of subcellular organelles (myofibrillar content, ATPase activity, SR and mitochondrial Ca2+ uptake)surrogate

Developmental increases in myocardial contractility are driven by changes in intracellular calcium handling, myofibrillar content, and ATPase activity.

Cite This Study

Nakanishi et al. (1984) studied this question.

synapsesocial.com/papers/6a76d1d81400807f0f1e6c27https://doi.org/10.1152/ajpheart.1984.246.4.h615
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