Key result
The Ca(2+) sensitivity of force generation decreased from embryonic day 19.5 (pCa50 6.05) to adult murine hearts (pCa50 5.64), a difference abolished by replacing native troponin with skeletal troponin.
Population
Murine hearts (Triton-skinned fibres) from embryonic day (E)10.5 to adult stage
Comparison
Replacement of native Tn complex with fast… vs Pre-replacement fibres and different…
Design
Preclinical
Authors
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Troponin I isoform switch drives murine Ca(2+) sensitivity maturation; leaves open translation to human development or disease.
Absolute Event Rate: 6.05% vs 5.64%
Major developmental changes in Ca(2+) sensitivity of murine myocardium originate primarily from the switch of slow skeletal troponin I to cardiac troponin I.
Siedner et al. (2003) studied Developmental changes in murine hearts. Developmental stage (embryonic vs adult) vs. Adult stage was evaluated on Ca(2+) sensitivity of force generation (pCa50). The Ca(2+) sensitivity of force generation decreased from embryonic day 19.5 (pCa50 6.05) to adult murine hearts (pCa50 5.64), a difference abolished by replacing native troponin with skeletal troponin.
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