Key result
The contractile apparatus of embryonic chicken heart is less sensitive to the depressant effects of acidosis than that of the adult heart, with age-dependent changes in calcium sensitivity correlating with troponin isoform switching.
Population
Small trabeculae dissected from left ventricles of Arbor Acre chickens between embryonic day 7 and young…
Comparison
Extracellular calcium variations, chemical… vs Different developmental stages and normal pH
Design
Preclinical
Authors
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No immediate clinical implications for acidosis management; leaves open troponin isoform effects on mammalian myocardial responses.
Embryonic chicken hearts exhibit higher calcium sensitivity and greater resistance to acidosis-induced contractile depression compared to adult hearts, correlating with troponin isoform switching.
Godt et al. (1991) studied Developing avian heart. Developmental age and acidosis was evaluated on Contractile properties (twitch force and calcium sensitivity). The contractile apparatus of embryonic chicken heart is less sensitive to the depressant effects of acidosis than that of the adult heart, with age-dependent changes in calcium sensitivity correlating with troponin isoform switching.
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