Population
Chick hearts during development (from 3 to 5 days in ovo to 3-4 days posthatched)
Comparison
Ca-channel agonist BAY K 8644 and PN200-100… vs Different developmental stages
Design
Preclinical
Authors
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Receptor upregulation without increased agonist sensitivity in chick ventricle; leaves open Ca-channel maturation mechanisms in mammalian development.
The abundance of dihydropyridine binding sites increases during chick ventricular development, but this is dissociated from the physiological response to a Ca-channel agonist.
Marsh et al. (1989) studied this question.
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