May 1, 1990Circulation ResearchOpen Access

Changes in myofibrillar activation and troponin C Ca2+ binding associated with troponin T isoform switching in developing rabbit heart.

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Population

5-day-old and 22-day-old rabbit hearts

Comparison

Maturation (22-day-old rabbit hearts) vs 5-day-old rabbit hearts

Design

Preclinical

Authors

JMJohn J. McAuliffeNational Society of Professional Engineers LGLizhu GaoUniversity of Illinois Chicago RSR. John SolaroGeneral Cardiology

Discussion

Member takes

Implication

Hypothesis-generating for troponin maturation in rabbits; leaves open translation to human cardiac development or therapy.

Structured PICO

Population

5-day-old and 22-day-old rabbit hearts

Intervention

Maturation (22-day-old rabbit hearts)

Comparator

5-day-old rabbit hearts

Outcome

Changes in Ca2+ dependence of myofibrillar ATPase activity, force generation, and troponin C Ca2+ bindingsurrogate

Postnatal maturation in rabbit hearts alters the Ca2+ activation and binding properties of myofibrillar troponin C, which may be driven by troponin T isoform switching.

Cite This Study

McAuliffe et al. (1990) studied this question.

synapsesocial.com/papers/6a207b49a40bcbc79e09a103 https://doi.org/10.1161/01.res.66.5.1204

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Changes in myofibrillar activation and troponin C Ca2+ binding associated with troponin T isoform switching in developing rabbit heart.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Changes in myofibrillar activation and troponin C Ca2+ binding associated with troponin T isoform switching in developing rabbit heart.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider