Key result
Multiple mechanisms participate in subsidiary pacemaker automaticity in the cat right atrium, including a cesium-sensitive component and a calcium-mediated component from the sarcoplasmic reticulum.
This preclinical study demonstrates that subsidiary pacemaker automaticity in the cat right atrium is driven by multiple ionic mechanisms, including a cesium-sensitive current and sarcoplasmic reticulum calcium release.
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Provides mechanistic insight into atrial automaticity; leaves open applicability to human physiology and arrhythmias.
Rubenstein et al. (1989) studied this question. Pharmacological agents (Cesium, Tetrodotoxin, Verapamil, Norepinephrine, Bay K 8644, Ryanodine) was evaluated on Mechanisms of subsidiary pacemaker automaticity (diastolic depolarization slopes and spontaneous cycle length). Multiple mechanisms participate in subsidiary pacemaker automaticity in the cat right atrium, including a cesium-sensitive component and a calcium-mediated component from the sarcoplasmic reticulum.
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