Population
Cat sinoatrial (SA) node cells, atrial latent pacemaker cells, and atrial and ventricular myocytes
Comparison
Inhibition of Na/Ca exchange and SR Ca-ATPase… vs Normal conditions and comparison across…
Design
Preclinical
Authors
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Animal data distinguish SR Ca roles in latent vs SA node pacemakers; hypothesis-generating for human arrhythmia mechanisms without clinical translation.
Enhanced diastolic SR Ca efflux contributes significantly to the generation of spontaneous activity in atrial subsidiary pacemakers and Ca-overloaded myocytes, but not in primary SA node cells.
Bassani et al. (1997) studied this question.
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