January 1, 2014ACTA HISTOCHEMICA ET CYTOCHEMICAOpen Access

Pacing-Induced Non-Uniform Ca²⁺ Dynamics in Rat Atria Revealed by Rapid-Scanning Confocal Microscopy

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Population

16 adult Wistar rats weighing 250-300 g (Langendorff-perfused excised hearts)

Design

Preclinical

Authors

YJYan JiangSouthwest University HTHideo TanakaKyoto Prefectural University of Medicine TMTaka‐aki MatsuyamaElectrophysiology

Discussion

Member takes

Implication

May inform rodent models of atrial Ca2+ instability; leaves open translation to human AF mechanisms.

Structured PICO

Population

16 adult Wistar rats weighing 250-300 g (Langendorff-perfused excised hearts)

Intervention

Electrical pacing at rates ranging from 1 Hz to 4 Hz (and up to 5 Hz)

Outcome

Intracellular Ca2+ ([Ca2+]i) dynamics (spatial uniformity, Ca2+ transients, wave-like propagation) in atrial myocytessurrogate

Rat atrial myocytes display a propensity for non-uniform systolic Ca2+ dynamics at high pacing frequencies, likely due to a paucity of t-tubules and impaired sarcoplasmic reticulum Ca2+ release, providing insights into atrial arrhythmogenesis.

Limitations

Observed under perfusion at room temperature
Contribution of sympathetic modulation was not considered because the hearts were excised

Cite This Study

Jiang et al. (2014) studied this question.

synapsesocial.com/papers/6a709e42e36a167817e26f43 https://doi.org/10.1267/ahc.14014

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Pacing-Induced Non-Uniform Ca²⁺ Dynamics in Rat Atria Revealed by Rapid-Scanning Confocal Microscopy

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Pacing-Induced Non-Uniform Ca²⁺ Dynamics in Rat Atria Revealed by Rapid-Scanning Confocal Microscopy

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider