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The stereoselective preparation and Pd-catalyzed cross-coupling reaction of boronates 2 provides a new general and convenient route to CF3-substituted triaryl ethenes 3, in which the CF3 and Ar3 groups are cis to each other. The synthetic potential was demonstrated by the total synthesis of panomifene (Ar1=Ar3=Ph, Ar2=4-(OHCH2CH2NHCH2CH2O)-C6H4). Bpin=(pinacolato)boryl.
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Liu et al. (2004) studied this question.
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