Key result
Vagus nerve stimulation is a promising immunomodulatory method that has shown positive experimental effects in stroke treatment, including neuroprotection and reduced infarct volume.
Why the study?
Stroke carries high morbidity and mortality, with inflammation playing a central role in its pathophysiology, making immunomodulatory approaches such as vagus nerve stimulation of clinical interest.
Does vagus nerve stimulation improve outcomes and provide immunomodulation in stroke?
Does vagus nerve stimulation improve outcomes and provide immunomodulation in stroke?
This review highlights the potential of vagus nerve stimulation as an immunomodulatory and neuroprotective therapy for stroke.
VNS merits clinical trials in stroke; leaves open whether immunomodulation improves human outcomes.
Stroke is a devastating cerebrovascular pathology with high morbidity and mortality. Inflammation plays a central role in the pathophysiology of stroke. Vagus nerve stimulation (VNS) is a promising immunomodulatory method that has shown positive effects in stroke treatment, including neuroprotection, anti-apoptosis, anti-inflammation, antioxidation, reduced infarct volume, improved neurological scores, and promotion of M2 microglial polarization. In this review, we summarize the current knowledge about the vagus nerve's immunomodulatory effects through the cholinergic anti-inflammatory pathway (CAP) and provide a comprehensive assessment of the available experimental literature focusing on the use of VNS in stroke treatment.
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Jelinek et al. (2023) conducted a review in Stroke. Vagus nerve stimulation (VNS) was evaluated. Vagus nerve stimulation is a promising immunomodulatory method that has shown positive experimental effects in stroke treatment, including neuroprotection and reduced infarct volume.
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