Key result
Additive administration of the oral prostacyclin analogue beraprost sodium achieved stabilization of pulmonary hemodynamics in a patient with primary pulmonary hypertension.
Why the study?
Does additive administration of beraprost sodium improve pulmonary hemodynamics in a patient with primary pulmonary hypertension refractory to conventional therapy?
Case Report (n=1)
Does additive administration of beraprost sodium improve pulmonary hemodynamics in a patient with primary pulmonary hypertension refractory to conventional therapy?
Oral beraprost sodium may be an effective additive therapy for stabilizing pulmonary hemodynamics in patients with primary pulmonary hypertension who deteriorate on conventional therapy.
Answers are grounded in this paper and cite their sources.
Supports beraprost addition in refractory primary pulmonary hypertension; hypothesis-generating and requires randomized confirmation before practice change.
A 65-year-old woman was admitted to our hospital because of exertional dyspnea in 1987. A diagnosis of primary pulmonary hypertension was confirmed by right heart catheterization. She had received conventional therapy in the outpatient clinic. She was readmitted with the deterioration of exertional dyspnea in 1995. Stabilization of pulmonary hemodynamics, while not achieved with conventional therapy, was achieved with additive administration of an oral prostacyclin (PGI2) analogue, beraprost sodium.
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Hashida et al. (1998) conducted a case report in Primary pulmonary hypertension (n=1). Beraprost sodium (oral prostacyclin analogue) vs. Conventional therapy was evaluated on Stabilization of pulmonary hemodynamics. Additive administration of the oral prostacyclin analogue beraprost sodium achieved stabilization of pulmonary hemodynamics in a patient with primary pulmonary hypertension.
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