What does this research mean for the field?

In patients with primary pulmonary hypertension, a highly responsive decrease in total pulmonary resistance index (>50%) during short-term prostacyclin challenge is associated with a longer disease evolution and significantly better two-year survival compared to lower vasodilator responses. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 1, 1996Circulation

Clinical Significance of the Pulmonary Vasodilator Response During Short-term Infusion of Prostacyclin in Primary Pulmonary Hypertension

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Why the study?

Does the degree of pulmonary vasodilatation during short-term prostacyclin infusion predict survival in patients with primary pulmonary hypertension?

Structured PICO

Does the degree of pulmonary vasodilatation during short-term prostacyclin infusion predict survival in patients with primary pulmonary hypertension?

Population

91 consecutive patients with primary pulmonary hypertension (PPH) who underwent right heart catheterization

Intervention

Short-term infusion of prostacyclin (PGI2) at 5 to 10 ng.kg-1.min-1 to assess vasodilator response (categorized as highly responding [>50% decrease in TPRi], moderately responding [20-50% decrease], or nonresponding [<20% decrease])

Comparator

Comparison among the three vasodilator response groups (highly responding vs moderately responding vs nonresponding)

Outcome

Survival rate at 2 years (excluding transplant recipients)hard clinical

Patients with primary pulmonary hypertension who exhibit a >50% decrease in total pulmonary resistance index during short-term prostacyclin challenge have a significantly better 2-year survival rate.

Discussion

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Implication

Acute vasodilator response may aid prognostication; leaves open whether it should guide therapy selection.

Cite This Study

Raffy et al. (1996) studied this question.

synapsesocial.com/papers/6a1bfc9d00ee29383e9d431f https://doi.org/10.1161/01.cir.93.3.484

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Clinical Significance of the Pulmonary Vasodilator Response During Short-term Infusion of Prostacyclin in Primary Pulmonary Hypertension

Structured PICO

Discussion

Implication

Cite This Study

Clinical Significance of the Pulmonary Vasodilator Response During Short-term Infusion of Prostacyclin in Primary Pulmonary Hypertension

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider