Key result
Biomarker testing, including natriuretic peptides and cardiac troponins, is primarily used for prognostication and risk stratification in advanced heart failure, while biomarker-guided treatment remains debated.
Why the study?
What is the diagnostic, prognostic, and therapeutic utility of biomarkers in the management of advanced heart failure?
What is the diagnostic, prognostic, and therapeutic utility of biomarkers in the management of advanced heart failure?
This review highlights that while biomarkers like natriuretic peptides and troponins are valuable for diagnosis and prognostication in advanced heart failure, their role in actively guiding therapy remains controversial.
Supports established diagnostic and prognostic roles for natriuretic peptides and troponins; leaves open whether biomarker-guided therapy improves outcomes in advanced heart failure.
Publications regarding the potential clinical utility of biomarker testing in the management of heart failure have been exponentially increasing over the last decade. The majority of non-cardiac biomarkers are commonly used to identify end-organ dysfunction or comorbidities. The diagnostic utility of natriuretic peptide testing has been well-established. Despite consistently demonstrating their prognostic values and some promising initial results, treatment guided by natriuretic peptide testing is still debated. Although cardiac troponins have been extensively used in diagnosis of myocardial injury, their primary use of biomarkers in advanced heart failure is prognostication and risk stratification. Congest Heart Fail. Congest Heart Fail. 2011;17:169-174.
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Nagarajan et al. (2011) conducted a review in Advanced heart failure. Biomarker testing was evaluated. Biomarker testing, including natriuretic peptides and cardiac troponins, is primarily used for prognostication and risk stratification in advanced heart failure, while biomarker-guided treatment remains debated.
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