Key result
Ferroptosis, driven by iron accumulation and lipid peroxidation, is implicated in the endocrine and metabolic disorders of polycystic ovary syndrome and represents a potential therapeutic target.
Why the study?
There is limited research on the role of ferroptosis in polycystic ovarian syndrome.
This review highlights the potential role of ferroptosis, driven by iron accumulation and lipid peroxidation, in the pathogenesis and potential personalized treatment of polycystic ovary syndrome.
Polycystic ovarian syndrome (PCOS) is a common heterogeneous reproductive endocrine metabolic disorder in women of reproductive age characterized by clinical and biochemical hyperandrogenemia, ovulation disorders, and polycystic ovarian morphology. Ferroptosis is a novel type of cell death driven by iron accumulation and lipid peroxidation. Ferroptosis plays a role in maintaining redox balance, iron metabolism, lipid metabolism, amino acid metabolism, mitochondrial activity, and many other signaling pathways linked to diseases. Iron overload is closely related to insulin resistance, decreased glucose tolerance, and the occurrence of diabetes mellitus. There is limited research on the role of ferroptosis in PCOS. Patients with PCOS have elevated levels of ferritin and increased reactive oxygen species in ovarian GCs. Studying ferroptosis in PCOS patients is highly important for achieving personalized treatment. This article reviews the progress of research on ferroptosis in PCOS, introduces the potential connections between iron metabolism abnormalities and oxidative stress-mediated PCOS, and provides a theoretical basis for diagnosing and treating PCOS.
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Wang et al. (2024) conducted a review in Polycystic ovary syndrome (PCOS). Ferroptosis was evaluated. Ferroptosis, driven by iron accumulation and lipid peroxidation, is implicated in the endocrine and metabolic disorders of polycystic ovary syndrome and represents a potential therapeutic target.
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