Key result
Perfluorocarbon nanoemulsions enable in vivo MRI visualization of post-infarct inflammation in preclinical models.
Why the study?
A new approach for in vivo visualization of inflammatory processes by magnetic resonance imaging using biochemically inert nanoemulsions of perfluorocarbons was developed and validated.
Can perfluorocarbons be used as a contrast agent for in vivo MRI visualization of inflammation after cardiac and cerebral ischemia in murine models?
Can perfluorocarbons be used as a contrast agent for in vivo MRI visualization of inflammation after cardiac and cerebral ischemia in murine models?
Perfluorocarbons can serve as a positive contrast agent for MRI detection of inflammation with high spatial resolution and specificity.
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May enable preclinical MRI tracking of post-MI inflammation in mice; leaves open human translation and validation.
Flögel et al. (2008) studied Acute cardiac and cerebral ischemia. Intravenous injection of perfluorocarbons (PFCs) was evaluated on In vivo visualization of inflammatory processes. Intravenous injection of perfluorocarbons enabled in vivo visualization of inflammatory processes by MRI, showing time-dependent infiltration into the border zone of infarcted areas in murine models.
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