Key result
A novel mixed Brugada electrocardiographic pattern was identified in the inferior leads of a patient, suggesting a possible association with non-compaction cardiomyopathy.
Why the study?
Brugada Syndrome diagnosis is usually assumed to be strictly limited to right precordial leads, but atypical electrocardiographic presentations can occur.
Case Report (n=1)
This case report provides the first description of a mixed Brugada pattern in inferior leads and proposes a potential shared genetic origin with non-compaction cardiomyopathy.
Answers are grounded in this paper and cite their sources.
May expand Brugada diagnosis beyond right precordial leads; hypothesis-generating and requires prospective validation before practice change.
Brugada Syndrome is a cardiac channelopathy closely related to lethal arrhythmias and sudden death in people without underlying structural pathology. The diagnosis is usually assumed with electrocardiographic patterns strictly limited to the right precordial leads, V1 or V2; but this is not so at all. In our article, we describe the clinical case of a patient with a novel and different electrocardiographic presentation: the typical diagnostic pattern was presented in a lower lead of the electrocardiogram, and next to it, another pattern was presented in a contiguous lead. In addition, we propose the possible association of a structural pathology (non-compaction cardiomyopathy) with Brugada Syndrome, since both share a possible common genetic origin in the SCN5A gene.
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Valdés et al. (2023) conducted a case report in Brugada Syndrome (n=1). A novel mixed Brugada electrocardiographic pattern was identified in the inferior leads of a patient, suggesting a possible association with non-compaction cardiomyopathy.
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