Key result
Provocative testing with antiarrhythmic drugs or pacing rate changes resulted in significantly larger QT interval changes in patients with Torsade de Pointes compared to those without (p<0.005).
Why the study?
Does monophasic action potential recording and specific provocations help evaluate TU abnormalities in patients with different causes of Torsades de Pointes?
Observational (n=26)
Does monophasic action potential recording and specific provocations help evaluate TU abnormalities in patients with different causes of Torsades de Pointes?
p-value: p=<0.005
Monophasic action potential recording is a useful method for evaluating TU abnormalities in patients with Torsades de Pointes, with different provocations required based on the underlying etiology.
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MAP recording may aid cause-specific TU evaluation in TdP; leaves open routine adoption pending confirmatory studies.
OHE et al. (1990) conducted an observational in Torsade de Pointes (n=26). Provocative testing (isoproterenol, antiarrhythmic drugs, pacing rate changes) vs. Patients without TdP was evaluated on QT interval change (p=<0.005). Provocative testing with antiarrhythmic drugs or pacing rate changes resulted in significantly larger QT interval changes in patients with Torsade de Pointes compared to those without (p<0.005).
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