Key result
Direct transplantation of unselected total bone marrow cells into acutely infarcted myocardium induced intramyocardial calcification in 28.5% of rats, compared to 0% with saline or stem cells.
Why the study?
Does intramyocardial injection of unselected bone marrow cells induce calcification in rats with acute myocardial infarction?
RCT (n=48)
Randomized into 3 groups
Does intramyocardial injection of unselected bone marrow cells induce calcification in rats with acute myocardial infarction?
Absolute Event Rate: 28.5% vs 0%
Direct transplantation of unselected bone marrow cells into acutely infarcted myocardium can induce significant intramyocardial calcification, raising safety concerns for this therapeutic approach.
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Alerts to potential BM cell risks in ischemic heart disease; leaves open clinical translation pending further study.
Yoon et al. (2004) conducted an RCT in Acute myocardial infarction (n=48). Total bone marrow cells (TBMCs) vs. Phosphate-buffered saline or BM multipotent stem cells was evaluated on Intramyocardial calcification. Direct transplantation of unselected total bone marrow cells into acutely infarcted myocardium induced intramyocardial calcification in 28.5% of rats, compared to 0% with saline or stem cells.
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