What question did this study set out to answer?

To investigate sustained blood pressure elevation due to lower body compression in pigs and dogs.

November 1, 1982Hypertension

Sustained blood pressure elevation to lower body compression in pigs and dogs.

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Randomized trial examines blood pressure elevation in pigs and dogs through lower body compression, suggesting a novel noninvasive method.

To investigate sustained blood pressure elevation due to lower body compression in pigs and dogs.
Constructed inflatable suits for compression of hindquarters and abdomen in pigs and dogs.
Measured blood pressure changes during 30 minutes of compression in pigs and 3 hours in dogs.
Evaluated vascular resistance and plasma norepinephrine levels in response to compression.
In pigs: blood pressure increased by 50/38 mm Hg, vascular resistance increased significantly, no baroreceptor-mediated bradycardia.
In dogs: blood pressure elevated by 44/53 mm Hg, with plasma norepinephrine rising from 179 to 975 pg/ml.
Treating pigs with trimethaphan reduced vascular resistance and blood pressure response, indicating additional vasoconstriction outside the suit.

Julius et al. (1982) studied this question.

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Randomized trial examines blood pressure elevation in pigs and dogs through lower body compression, suggesting a novel noninvasive method.