Key result
A closed-loop model of the cardiovascular system complemented by a coronary bed model suggests the heart plays an active role in restoring haemodynamic parameters to physiological values.
This computational model demonstrates the active role of the heart and coronary bed in autoregulating and restoring haemodynamic equilibrium.
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Model suggests cardiac autoregulation; leaves open clinical translation pending experimental validation.
To investigate cardiovascular haemodynamics under normal and pathological conditions, a closed-loop model of the cardiovascular system already presented in the literature, has been complemented by a model of the coronary bed. Oxygen available to the myocardium is strictly related to the coronary blood flow; we have developed threshold criteria which correlate cardiac output with the coronary flow. The system utilizes control systems related to the cardiac contractility and frequency, and imitates feedback mechanisms peculiar to the heart. The work exemplifies the autoregulation of events that occur when the equilibrium of the system is disturbed. It is suggested that the heart plays an active role in trying to restore the haemodynamic parameters to their physiological values.
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Mantero et al. (1992) conducted a review in Cardiovascular haemodynamics under normal and pathological conditions. Closed-loop model of the cardiovascular system with a coronary bed model was evaluated. A closed-loop model of the cardiovascular system complemented by a coronary bed model suggests the heart plays an active role in restoring haemodynamic parameters to physiological values.
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