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An unprecedented method for the construction of thiazole-2-thiones via an oxidative cascade cyclization strategy is described. The novel protocol involves the simultaneous formation of two C—S bonds and a C═S bond on the structure of enaminones in a single operation through a cascade of C(sp 2 )—H/C(sp 3 )—H bond sulfurations and C(sp 3 )–H bond thiocarbonylation. This transformation allows for the efficient synthesis of thiazole-2-thiones with broad tolerance in moderate to excellent yields from simple enaminones with elemental sulfur.
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Zhang et al. (2021) studied this question.
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