Key result
An ASFV dUTPase-deletion mutant replicated as efficiently as parental virus in Vero cells but only to 10% or less of parental virus in swine macrophages.
ASFV dUTPase is required for productive infection in nondividing swine macrophages but dispensable in dividing Vero cells.
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Enables ASFV antiviral targeting via dUTPase inhibition; leaves open in vivo efficacy and therapeutic translation.
Oliveros et al. (1999) studied African swine fever virus infection. ASFV dUTPase-deletion mutant (vDeltaE165R) vs. Parental virus was evaluated on Viral replication in swine macrophages. An ASFV dUTPase-deletion mutant replicated as efficiently as parental virus in Vero cells but only to 10% or less of parental virus in swine macrophages.