Painful diabetic peripheral neuropathy: real-world comparison between topical treatment with lidocaine 700 mg medicated plaster and oral treatments

Michael A. Überall; Irmgard Bösl; Els Hollanders; Ingo Sabatschus; Mariëlle Eerdekens

doi:10.1136/bmjdrc-2022-003062

November 1, 2022BMJ Open Diabetes Research & CareOpen Access

Painful diabetic peripheral neuropathy: real-world comparison between topical treatment with lidocaine 700 mg medicated plaster and oral treatments

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Key Points

This study aimed to compare the efficacy and tolerability of topical lidocaine plaster versus oral medications in patients with painful diabetic peripheral neuropathy.
Subgroup analysis of a 24-week retrospective cohort study using data from the German Pain eRegistry.
732 datasets per treatment group were matched using propensity score matching.
Primary endpoint measured was the absolute change in pain intensity over treatment duration.
Lidocaine plaster showed a mean pain reduction of -30.2 mm, versus -17.0 mm for oral medications over 24 weeks (p<0.001).
Significantly fewer DRAEs reported for lidocaine (9.6%) compared to oral treatments (61.6%, p<0.001).
Lidocaine treatment led to improved quality of life and reduced need for concomitant analgesics compared to oral medications.

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Implication

Retrospective cohort study compares pain relief and tolerability of lidocaine plaster and oral medications in diabetic neuropathy, indicating lidocaine may be preferable.

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Cite This Study

Überall et al. (2022) studied this question.

synapsesocial.com/papers/6a6c44db47a1bfb288f37922 https://doi.org/10.1136/bmjdrc-2022-003062

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Painful diabetic peripheral neuropathy: real-world comparison between topical treatment with lidocaine 700 mg medicated plaster and oral treatments

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Painful diabetic peripheral neuropathy: real-world comparison between topical treatment with lidocaine 700 mg medicated plaster and oral treatments

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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