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The research aims to analyze tumor heterogeneity and immune interactions in natural killer/T-cell lymphoma using multiomic approaches.

July 31, 2026Nature CommunicationsOpen Access

Single-cell profiling of natural killer/T-cell lymphoma reveals stratified immune features and potential therapeutic implications

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Randomized trial demonstrates immune feature stratification in natural killer/T-cell lymphoma, suggesting new therapeutic options.

The research aims to analyze tumor heterogeneity and immune interactions in natural killer/T-cell lymphoma using multiomic approaches.
Single-cell RNA sequencing of 63 NKTCL samples
Integration of spatial transcriptomics, bulk transcriptomics, proteomics, and metabolomics
Identification of four main gene expression meta-programs associated with tumor features
MP1 shows immune-exhaustion with high PD-L1 expression, indicating potential for immune checkpoint therapy.
MP2 has an immune-desert phenotype with increased HDAC2 and MKI67, highlighting epigenetic factors in tumor growth.
MP3 features JAK/STAT pathway activation and a myeloid-dominant environment linked to aggressive disease.

Cao et al. (2026) studied this question.

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