Disrupted bone homeostasis underlies skeletal deformities in South China carp (Cyprinus rubrofuscus Lacepède, 1803): Evidence from micro-CT, transcriptomics, and histological analyses
Identifies disrupted bone homeostasis as a cause of skeletal deformities in South China carp, highlighting implications for aquaculture sustainability.
Key Points
To investigate the causes of skeletal deformities in South China carp and their impact on growth and swimming performance.
Utilized micro-CT imaging to assess bone structure and mineral density.
Conducted transcriptomic analysis on rib tissues to identify gene expression differences between deformed and normal carp.
Measured serum markers of bone formation and absorption.
Detected significantly reduced bone mineral density and volume in deformed carp (p<0.05).
Identified 2922 upregulated and 4042 downregulated genes related to bone metabolism in the deformed group.
Confirmed increased osteoblast and osteoclast activity in deformed fish.