Report finds metabolic support improves outcomes in acute liver failure from NBAS mutation in children, suggesting genetic causes need consideration.
early induction of anabolism with intravenous glucose and parenteral lipid has shown to ameliorate hepatic crises [3].The vast majority recover completely without need for liver transplantation, although it may be considered in refractory cases [4].In India, where infectious etiologies remain the predominant cause of ALF, genetic causes should be considered in those without an identifiable etiology.NBAS mutation should be suspected in recurrent fevertriggered ALF with complete recovery.Prompt fever control and metabolic support should be instituted.
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Augustine et al. (2026) studied this question.
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