Molecular docking studies, synthesis and evaluation of novel sulfonamide-containing 6-(aminothiazole) derivatives of flavone as anticancer agents

A series of novel sulfonamide derivatives of 6-(aminothiazole) flavones have been designed, synthesized and evaluated in MTT cell proliferation assay against three human cell lines, HeLa (Cervical carcinoma), Hep3B (Hepatocytic carcinoma) and MCF-7 (Breast carcinoma). All the compounds were analyzed by spectroscopic methods. Compound 10c IC50 of 21.93 µM is the good inhibitor of MCF-7 cell line. In sulfonamide series 10h with IC50 values 20.32 µM and 17.23 µM against HeLa and HeP3B cell lines is showing activity comparable with methotrexate. Docking results also have supported above observations by indicating that compounds are held in the active pocket by combination of various hydrogen and hydrophobic interactions.