Research Article demonstrates novel O2 activation in oxidative coupling for pharmaceutical synthesis, suggesting industrial potential.
In Research Article (e1664539), Zhen Guo, Meng Dan, and co-workers first established a novel “electron donor-assisted HECs-mediated” O2 activation mechanism. Non-noble high-entropy sulfide nanocrystals successfully drive diverse oxidative coupling reactions (forming S–N, C–S, and C–N bonds) under ambient conditions, achieving various pharmaceutical synthesis, scalable to mol-scale production, showcasing its significant potential for direct industrial application. Art by Run-Long Qi.
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Qi et al. (2026) studied this question.
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