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This study aims to reveal the genomic and epigenomic factors underlying barley evolution and domestication.

July 31, 2026PlantsOpen Access

Integrated Comparative Genomics and Population Genomics Reveal the Genomic and Epigenomic Basis of Barley (Hordeum vulgare) Evolution and Domestication

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Randomized trial uncovers genomic features of barley evolution in wild and domesticated accessions, suggesting implications for breeding.

This study aims to reveal the genomic and epigenomic factors underlying barley evolution and domestication.
Integrated comparative genomics, methylomics, and population genomics analyses of 291 barley accessions
Conducted Hi-C analyses to investigate chromatin structure
Identified candidate genes associated with domestication in relation to metabolic pathways.
Identified 243 candidate domestication-associated genes enriched in starch and sucrose metabolism pathways.
Observed slow linkage disequilibrium decay in barley accessions.
Found distinct cytosine methylation landscapes and differences in chromatin compartmentalization between barley varieties.

Yue et al. (2026) studied this question.

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