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Shows declines in adherence to antiretroviral therapy among adults with HIV, suggesting crucial implications for treatment effectiveness.
Among 250 adults with HIV (median age 34 years, IQR 27–42; 78% women), tenofovir diphosphate (TFV-DP) concentrations in dried blood spots and electronic adherence declined over 12 months. Mean TFV-DP fell from 1219 to 939 fmol/punch in men and 1148 to 894 in women, while electronic adherence declined from 65 to 49% in men and from 62 to 52% in women. Visit predicted declines in TFV-DP ( F = 7.17, P < 0.001) and electronic adherence ( F = 2.57, P = 0.003).
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Ferraris et al. (2026) studied this question.
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