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July 31, 2026Journal of PeriodontologyOpen Access

Periodontitis and breast cancer risk: A systematic review with meta‐epidemiological analysis

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Authors

RPRhayssa Kuhn PeitoxoCACatiusse Crestani Del AgneseMCMateus Cassol Comassetto

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Overview

Meta-epidemiological analysis demonstrates modest breast cancer risk associated with periodontitis, suggesting methodological effects.

Key Points

  • The study aims to evaluate how study methodologies impact estimates of breast cancer risk associated with periodontitis.
  • Systematic search of cohort and case-control studies in electronic databases up to February 2025.
  • Study quality assessed using the Newcastle-Ottawa Scale.
  • Meta-analyses and meta-regression performed to analyze variability in effect estimates.
  • Overall pooled estimate shows a 19% higher risk of breast cancer in women with periodontitis (RR = 1.19; 95% CI, 1.05-1.34).
  • Attenuated estimates in prospective studies (RR = 1.05) compared to case-control studies (RR = 1.54).
  • Higher estimates found in lower-quality studies (RR = 2.10) versus high-quality studies (RR = 1.09).

Cite This Study

Peitoxo et al. (2026) studied this question.

synapsesocial.com/papers/6a6c473c747664a1aa73c3efhttps://doi.org/10.1002/jper.70171
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