Dynamical Instability in Motor Neuron Disease - An open-science programme: stability, early-warning signals, and the neuromuscular junction

An open-science research programme in Motor Neuron Disease / ALS, asking whether the stability of the body's compensation for nerve damage — not just the amount of loss — carries an earlier warning signal than the measures clinics use today. The current focus applies critical-slowing-down analysis an early-warning method proven in seizure forecasting — to the neuromuscular junction, whose instability ALS clinics have recorded for decades but never read dynamically. This sits within a broader framework treating ALS as a progressive loss of multiscale stability and error tolerance, with structural degeneration as a late expression of earlier instability. Start here → the preprint in 01_START_HERE_Preprint. The work is deliberately provisional, falsifiable, and hypothesis-generating. It claims no mechanism and no cure; it proposes testable ideas and the means to test or break them. Independent, self-taught, built in the open. Licence: CC BY 4.0. Collaboration and critique welcomed — clinicians, modellers, and experimentalists especially. Contact: michael_nolan32@outlook.com