Universal Biomaterial Hydrogel Platform with Thermo-Reactive, Mucoadhesive, and Buffering-Hemostatic Properties and Method for Its Preparation

Combining hyaluronic acid and calcium carbonate represents one of the most promising theoretical concepts in medical device development. Hyaluronic acid provides structure, softness, protection, and hydration as a biological matrix, whereas calcium carbonate delivers active acid-neutralizing capacity and hemostatic stimulation. Key Ingredients & Molecular Mechanism for thermo-reactive hydrogel Poloxamer 407 (Pluronic F-127): A synthetic non-ionic block copolymer exhibiting reverse thermogelling behavior. At low temperatures, polymer chains float freely in solution; at , hydrophobic blocks aggregate into tightly packed micelles, forming a firm gelatinous 3D network. Sodium Hyaluronate: High-molecular-weight glycosaminoglycan providing bioadhesion, CD44 receptor binding, tissue hydration, and scar-free epithelial healing. Precipitated Calcium Carbonate (PCC): Ultra-fine micro- or nano-sized mineral particles acting as a localized acid buffer and hemostatic reservoir. The hydrogel is suitable for intestinal, dermatological, and oral applications. Initially conceptualized during a tumor treatment simulation, the hydrogel platform was subsequently expanded for dermatological and oral applications.