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July 31, 2026Advanced Healthcare MaterialsOpen Access

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

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Authors

KBKimberly R. BennettYVYann VanrobaeysTTTessy Teboh

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Overview

Randomized trial reveals endothelial remodeling in diffuse midline glioma, suggesting new therapeutic strategies.

Key Points

  • The aim is to create a vascular model of the diffuse midline glioma blood-brain-tumor barrier to understand tumor interactions.
  • Developed an in vitro model with patient-derived DMG cells and human brain endothelial cells in a microfluidic chip.
  • Conducted perfusion studies and transcriptomic analysis using scRNAseq to assess vascular behavior and gene expression.
  • Compared the vascular permeability and gene expression under different experimental conditions, including TNFα stimulation.
  • No significant changes in vascular permeability were observed in the presence of tumor cells.
  • Significant differential gene expression was detected between BBB and DMG-BBTB compared to inflammatory controls (TNFα).
  • DMG cells exhibited a mesenchymal-like phenotype, indicating altered tumor-endothelial interactions.

Cite This Study

Bennett et al. (2026) studied this question.

synapsesocial.com/papers/6a6c4794747664a1aa73d1bfhttps://doi.org/10.1002/adhm.71474
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 1822 Deciphering the Proteomic Landscape: Understanding the Tumor Microenvironment in Diffuse Midline Glioma2024
  2. 2Abstract 4875: Modeling GBM-vasculature interaction on chip2026
  3. 3Consequences of irradiation on blood-brain tumor barrier model of Diffuse Midline Glioma: characterization of physical and metabolic properties2026
  4. 4ID #195 A Neuroimmune-Competent Human Brain Organoid Model for Mechanism-Guided Drug Discovery in Diffuse Midline Glioma2026
  5. 5Abstract A048: Development and validation of a microfluidic cell culture model for examining cerebral microvascular barrier responses to the tumor microenvironment2024