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July 31, 2026AJP Cell Physiology

Subcellular Regulation of Ferroptosis: Roles of Individual Intracellular Organelles and Crosstalk

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Authors

CPChanon PiamsiriJGJudith K. GwathmeyLXLai‐Hua Xie

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Overview

Comprehensive review detailing how organelles regulate ferroptosis, affecting cellular death pathways and disease management.

Key Points

  • The aim is to explore the role of various intracellular organelles in the modulation of ferroptosis.
  • Review of mechanistic insights into organelle-specific regulation of ferroptosis.
  • Analysis of inter-organelle interactions affecting ferroptotic sensitivity.
  • Discussion of therapeutic opportunities and experimental challenges in targeting ferroptosis.
  • Mitochondria enhance ferroptosis by controlling metabolic activities and reactive oxygen species generation.
  • Lysosomes influence ferroptotic sensitivity through iron mobilization and lipid peroxidation.
  • The ER impacts ferroptosis by altering lipid biosynthesis and modulating antioxidant defenses.

Cite This Study

Piamsiri et al. (2026) studied this question.

synapsesocial.com/papers/6a6c4794747664a1aa73d2e4https://doi.org/10.1152/ajpcell.00334.2026
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