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July 31, 2026ImmunoOpen Access

Engineering an Innovative Chimeric Multi-Epitope RNA-Based Vaccine Against Neonatal Calf Diarrhea Pathogens (Bovine Coronavirus, Bovine Rotavirus, and Escherichia coli K99): An In Silico-Based Analysis

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Authors

MHMariam HassanAAAmjed AlsultanDADhama AlSallami

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Overview

Randomized trial designs a multi-epitope RNA vaccine against neonatal calf diarrhea pathogens, suggesting a new prevention method.

Key Points

  • The primary aim is to design a multi-epitope mRNA vaccine targeting pathogens responsible for neonatal calf diarrhea.
  • Utilized immunoinformatic tools and molecular modeling to identify potential epitopes.
  • Conjugated fifteen selected epitopes with linkers and a built-in adjuvant.
  • Conducted molecular docking to analyze binding affinity with bovine toll-like receptors.
  • Developed a stable, antigenic, and non-allergenic vaccine candidate against NCD pathogens.
  • Demonstrated strong binding affinity between the vaccine candidate and toll-like receptors TLR2 and TLR4.
  • Molecular docking analysis indicated low energy and high stability of the binding interactions.

Cite This Study

Hassan et al. (2026) studied this question.

synapsesocial.com/papers/6a6c479e747664a1aa73d3adhttps://doi.org/10.3390/immuno6030048
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