Key result
Cardiac sympathetic neuronal PET imaging provides information on sympathetic innervation alterations and serves as a useful tool for risk stratification of severe cardiovascular complications.
Why the study?
Can positron emission tomography (PET) with radiolabeled catecholamines and adrenoreceptor ligands assess cardiac sympathetic innervation and stratify risk in patients with cardiac diseases?
Can positron emission tomography (PET) with radiolabeled catecholamines and adrenoreceptor ligands assess cardiac sympathetic innervation and stratify risk in patients with cardiac diseases?
PET imaging of the cardiac sympathetic nervous system is a valuable tool for assessing autonomic alterations and stratifying risk in various heart diseases.
This article summarizes data of the studies with the use of positron emission tomography (PET) and devotes technical aspects and clinical application of PET for assessment of the autonomic nervous system of the heart in patients with cardiac diseases. According to the results of experimental and clinical studies PET with radiolabeled сatecholamines and adrenoreceptor ligands provides us with information about alteration of cardiac sympathetic innervation at different steps of neurotransmission. It plays a key role in the progression of various heart diseases such as ischemia, diabetes mellitus, heart failure and noncoronary arrhythmia. Cardiac sympathetic neuronal PET imaging seems to be a good tool for the stratification of the risk of the severe cardiovascular complications.
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Рыжкова et al. (2008) conducted a review in Cardiac diseases. Positron emission tomography (PET) with radiolabeled catecholamines and adrenoreceptor ligands was evaluated. Cardiac sympathetic neuronal PET imaging provides information on sympathetic innervation alterations and serves as a useful tool for risk stratification of severe cardiovascular complications.
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