Key result
PET imaging maps myocardial metabolism, perfusion, inflammation, fibrosis, and sympathetic activity in heart failure.
Why the study?
Imaging modalities are increasingly used to assess heart failure pathophysiology, and PET imaging can visualize key biological processes in vivo using various radiopharmaceuticals.
PET imaging is a valuable non-invasive tool for evaluating the underlying pathophysiology of heart failure, with potential for present and future clinical applications.
Offers potential for refined HF phenotyping; leaves open integration into routine care without outcome data.
Imaging modalities are increasingly being used to evaluate the underlying pathophysiology of heart failure. Positron emission tomography (PET) is a non-invasive imaging technique that uses radioactive tracers to visualize and measure biological processes in vivo. PET imaging of the heart uses different radiopharmaceuticals to provide information on myocardial metabolism, perfusion, inflammation, fibrosis, and sympathetic nervous system activity, which are all important contributors to the development and progression of heart failure. This narrative review provides an overview of the use of PET imaging in heart failure, highlighting the different PET tracers and modalities, and discussing fields of present and future clinical application.
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Tersalvi et al. (2023) conducted a review in Heart failure. Positron emission tomography (PET) was evaluated. Positron emission tomography (PET) imaging provides valuable information on myocardial metabolism, perfusion, inflammation, fibrosis, and sympathetic nervous system activity in heart failure.
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