DINCH induces intestinal toxicity through "ROS-ENO1-PA-lipid peroxidation" axis: An integrated approach combining network toxicology and experimental validation.

July 28, 2026

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Key Points

This research aims to investigate the mechanism of intestinal toxicity induced by DINCH, focusing on the ROS-ENO1 pathway.
Integrated approach combining network toxicology and experimental validation to assess DINCH toxicity.
Analysis of oxidative stress markers related to the ROS-ENO1 pathway.
Evaluation of lipid peroxidation levels in intestinal models.
DINCH exposure significantly increased ROS levels (p<0.01), leading to elevated oxidative stress markers.
ENO1 upregulation was observed alongside enhanced lipid peroxidation, implicating this pathway in toxicity.
Findings suggest a need for revising DINCH safety thresholds based on detected toxicity mechanisms.

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Reveals oxidative stress in intestinal toxicity from DINCH exposure, suggesting revised safety thresholds.

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Kang et al. (2026) studied this question.

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