A Study on the Effects of Aqueous Solution of Mangifera Indica (Mango Peel) on the Histology of the Ovaries of Albino Wistar Rats Exposed to Aluminium Chloride Toxicity.

Background: Mango is a popular fruit known for its sweet flavor and various commercial uses, such as in fruit salads and juices. The ovary, a distinctive feature of a female is responsible for the production of ova and undergo cyclical changes on which fertility and other characteristics of a developing female heavily depend. AIM: The study was aimed at giving a concise insight into the effect of aqueous solution of Mangifera indica on the hormonal profile and histology of the the ovaries of female albino wistar rats following aluminum toxicity. Material and methods: Twenty-five rats were divided into five groups; Group A (control); Group B (aluminium exposure only); after aluminium exposure, Group C and D received extract twice and three times daily respectively; and Group E received extract continuously. Ovaries were harvested for histological analysis using haematoxylin, and eosin (H&E) standard procedure. Furthermore, Follicular stimulating and Luteinizing hormones were assessed. Results: Results obtained showed a dose dependent increase in body weight across the groups. Histological analysis showed aluminum administration induced structural alteration in ovarian tissue, including follicular degeneration and disrupted morphology, while extract demonstrated protective effects that improved ovarian architecture and restored hormone levels in dose-dependent manner. The obtained hormonal analysis showed a dose dependent increase in Luteinizing hormone (LH) and Follicle Stimulating Hormonal (FSH) in groups administered with extract when compared to the control group. Conclusion: This finding suggests that mango peel often discarded as waste, contains bioactive compounds capable of mitigating aluminum-induced reproductive toxicity. The study highlights the potential of mango peel extracts as a natural, effective therapeutic agent in reproductive medicine.