What is the clinical evidence from this study?

Study design: Other. Population: Neuronal nitric oxide synthase expression. Intervention: Alternative splicing of nNOS. Primary outcome: Identification of nNOS transcripts.

September 15, 1997Journal of Clinical InvestigationOpen Access

Tissue- and development-specific expression of multiple alternatively spliced transcripts of rat neuronal nitric oxide synthase.

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Key result

The rat neuronal nitric oxide synthase gene expresses at least three alternatively spliced transcripts (nNOSa, nNOSb, and nNOSc) with distinct tissue- and development-specific patterns.

Authors

MLM A LeeHarvard University LCLe CaiWenzhou University NHNorbert HübnerHeart Failure & Transplant

Discussion

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Implication

Distinct nNOS splice variants suggest isoform-specific regulation; leaves open human cardiovascular relevance.

PICO

Population

Basic science study investigating the transcriptional variants of neuronal nitric oxide synthase in rat tissues and PC12 cells.

Exposure / Comparator

Alternative splicing of nNOS

Primary Outcome

Identification of nNOS transcripts

Limitations

Further studies using in situ hybridization are necessary to elucidate the spatial and temporal expression of nNOS-mRNA on a tissular and cellular level.
Any critical assessment concerning the functional relevance of these sequence elements and the characterization of putative promoters must await the results of specific experiments.

Cite This Study

Lee et al. (1997) studied Neuronal nitric oxide synthase expression. Alternative splicing of nNOS was evaluated on Identification of nNOS transcripts. The rat neuronal nitric oxide synthase gene expresses at least three alternatively spliced transcripts (nNOSa, nNOSb, and nNOSc) with distinct tissue- and development-specific patterns.

synapsesocial.com/papers/6a6c55b0050bc01bbbcbaa18 https://doi.org/10.1172/jci119673

View Full Paper

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Bookmark

Tissue- and development-specific expression of multiple alternatively spliced transcripts of rat neuronal nitric oxide synthase.

Discussion

Member takes

Implication

PICO

Limitations

Cite This Study

Tissue- and development-specific expression of multiple alternatively spliced transcripts of rat neuronal nitric oxide synthase.

Discussion

Member takes

Implication

PICO

Limitations

Cite This Study

Also Consider

Also Consider