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Image enhancement: Core–shell [email protected]3O4 urchin-shaped nanoparticles can be synthesized by means of an anisotropic etching process and used as a pH-activatable T1 contrast agent for magnetic resonance imaging. The manganese ions released from the MnO phase in the low-pH sites within tumor cells lead to an enhanced T1 contrast image for the entire tumor mass.
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Kim et al. (2011) studied this question.
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