Key result
Addition of clarithromycin to long-term digoxin therapy induced digoxin toxicity in two patients with stable renal function.
Why the study?
Does the addition of clarithromycin induce digoxin toxicity in patients on long-term digoxin therapy?
Case Report (n=2)
Does the addition of clarithromycin induce digoxin toxicity in patients on long-term digoxin therapy?
Concomitant use of clarithromycin and digoxin can lead to digoxin toxicity, requiring close clinical and laboratory monitoring.
May warrant vigilance for digoxin toxicity with clarithromycin co-use; case reports leave incidence and causality open for prospective study.
Two patients experienced clarithromycin-induced digoxin toxicity. Both had stable renal function within normal limits and had been maintained on a consistent dosage of digoxin. No changes in drug therapy had been made except for the addition of clarithromycin. Administration of clarithromycin to patients receiving long-term digoxin therapy may induce digoxin toxicity. When concomitant therapy is employed, patients should be closely monitored for clinical signs and symptoms of digoxin toxicity, and digoxin concentrations should be measured to avoid it.
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Guerriero et al. (1997) conducted a case report in Digoxin toxicity (n=2). Clarithromycin was evaluated on Digoxin toxicity. Addition of clarithromycin to long-term digoxin therapy induced digoxin toxicity in two patients with stable renal function.
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