Key result
Schizophrenia was associated with significantly higher overall pregnancy and birth complication scores, particularly long labor, compared to matched controls.
Why the study?
Are pregnancy and birth complications more frequent in individuals who later develop schizophrenia compared to matched controls?
Population
34 adopted schizophrenics and their matched controls, and 29 matched pairs of nonadopted schizophrenics and…
Comparison
Schizophrenia (case status) vs Matched controls without schizophrenia
Design
Case-control
Authors
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Supports perinatal complications as schizophrenia risk markers; hypothesis-generating, requires prospective confirmation before clinical relevance.
Case-Control (n=126)
Are pregnancy and birth complications more frequent in individuals who later develop schizophrenia compared to matched controls?
Pregnancy and birth complications, particularly long labor, are significantly associated with the later development of schizophrenia in both adopted and non-adopted individuals.
Jacobsen et al. (1980) conducted a case-control in Schizophrenia (n=126). Schizophrenia vs. Matched controls was evaluated on Pregnancy and birth complications (PBCs) scores. Schizophrenia was associated with significantly higher overall pregnancy and birth complication scores, particularly long labor, compared to matched controls.
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