Key result
Local production and secretion of the cytokines IL-1 and TNF promotes the induction of postcoxsackievirus autoimmune myocarditis in mice.
Why the study?
Does local production of IL-1 and TNF promote the induction of postcoxsackievirus autoimmune myocarditis in mice?
Does local production of IL-1 and TNF promote the induction of postcoxsackievirus autoimmune myocarditis in mice?
Local production of IL-1 and TNF by inflammatory cells in the heart promotes the induction of postinfectious autoimmune myocarditis in a murine model.
Hypothesis-generating in murine postviral myocarditis; leaves open translation to human disease or therapy.
We have previously reported that B10.A (H-2a) mice, which are resistant to the induction of postcoxsackievirus autoimmune myocarditis, become susceptible upon treatment with LPS, IL-1, or TNF. In this study, we show that the development of autoimmune myocarditis is associated with infiltration of the heart by inflammatory cells that secrete the cytokines IL-1 and TNF. Local secretion of these cytokines contributes to increased levels of IL-1 and TNF in the serum. Thus, local production of cytokines promotes the induction of this postinfectious autoimmune disease.
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Lane et al. (1993) studied Coxsackievirus-induced autoimmune myocarditis. LPS, IL-1, or TNF was evaluated on Development of autoimmune myocarditis and infiltration of the heart by inflammatory cells. Local production and secretion of the cytokines IL-1 and TNF promotes the induction of postcoxsackievirus autoimmune myocarditis in mice.
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