Local production and secretion of the cytokines IL-1 and TNF promotes the induction of postcoxsackievirus autoimmune myocarditis in mice.
Does local production of IL-1 and TNF promote the induction of postcoxsackievirus autoimmune myocarditis in mice?
Local production of IL-1 and TNF by inflammatory cells in the heart promotes the induction of postinfectious autoimmune myocarditis in a murine model.
We have previously reported that B10.A (H-2a) mice, which are resistant to the induction of postcoxsackievirus autoimmune myocarditis, become susceptible upon treatment with LPS, IL-1, or TNF. In this study, we show that the development of autoimmune myocarditis is associated with infiltration of the heart by inflammatory cells that secrete the cytokines IL-1 and TNF. Local secretion of these cytokines contributes to increased levels of IL-1 and TNF in the serum. Thus, local production of cytokines promotes the induction of this postinfectious autoimmune disease.
Lane et al. (Sun,) conducted a other in Coxsackievirus-induced autoimmune myocarditis. LPS, IL-1, or TNF was evaluated on Development of autoimmune myocarditis and infiltration of the heart by inflammatory cells. Local production and secretion of the cytokines IL-1 and TNF promotes the induction of postcoxsackievirus autoimmune myocarditis in mice.